Agenus

  • Manufacturing Associate

    Job Locations US-CA-Berkeley
    Job ID
    2018-1447
    Category
    Manufacturing
  • Overview

    At Agenus, we believe vertical integration is critically important. We have taken aggressive steps to accomplish this, facilitating rapid and efficient advancement of our antibody programs and minimizing reliance on external vendors. Through innovation and strategic acquisitions, Agenus scientists have access to an unparalleled capabilities tool kit.

    Performing early discovery work on novel antibodies, including validating targets and identifying lead compounds, is highly enabled by our mammalian, phage and yeast display platform technologies. Lead optimization and candidate verification benefit from our integrated discovery platforms, including our mammalian Retrocyte DisplayTM and HT-CHO technologies. These integrated platforms, along with our structural and computational biology capabilities, positions us to precisely control and design the properties of our antibodies so that we can generate products with the desired properties to enhance their efficacy.

    We have also built our in-house cell line development and manufacturing capabilities, which we regard as an important advantage in an environment of increasingly tighter third party manufacturing capacities.

    This integration of our discovery, development and manufacturing capabilities provides Agenus with unique advantages in an era when quality, efficiencies and speed of development and commercialization are paramount to successfully developing a new generation of I-O biopharmaceutical therapeutics.

    Who are we looking for?

    • An enthusiastic and knowledgeable Manufacturing Associate to join our Downstream Purification group of the Manufacturing team.
    • A Manufacturing Associate who loves working on multiple projects in a fast-paced, cross-functional environment
    • A candidate that can leverage their knowledge of chromatography, virus inactivation, filtration (dead-end, tangential flow, final fill) to support team objectives

    What are we looking for?

    • Ownership: A partner to jointly own our company’s goals, execution and success
    • Working together: A colleague to thrive on collaboration with our teammates
    • Loving what you do: A team member with positive energy that is passionate about our mission
    • Engagement: An active participant that enjoys sharing ideas, contributing with others, and engaging in our projects and process improvements.

    What are we offering?

    • A dynamic, fun and learning culture
    • Exposure to pioneering science and the full scope of the drug development process
    • Innovative thinking: speed of adopting new technologies, clear prioritization, using analytics to accelerate agile development
    • A unique opportunity to help develop the platforms and strategy of a burgeoning company
    • Team with broad experience and passion about the science
    • Career support and learning opportunities within the Manufacturing group
    • Membership within a growing, dynamic and collegial organization
    • New cutting edge technology, and education via side-by-side interaction with downstream purification process development and potential cross-training

    The Manufacturing Associate will have the opportunity to coordinate and collaborate with other cross-functional departments, including Quality, Facilities, Procurement, etc. This position requires independent execution of quality systems (includes: initiation of critical work orders, change requests, deviations, corrective action preventative action (CAPA)).  There will be times when work schedules change to accommodate the processing schedule. Contribution and participation will be required for additional assignments and projects including: report writing, data analysis, experiment/validation execution, data compilation/summarization, etc.

    Responsibilities

    ESSENTIAL DUTIES:

    • Monitor fermentation and purification operations (including trouble-shooting and diagnosis of instruments, equipment, process, etc.)
    • Set-up, prepare, and operate manufacturing equipment/labware/assemblies (including: filtration skid, chromatography skid, fermenter, autoclave/sterilizer, bench top meters (pH/conductivity/osmometer), etc.) in accordance with current good manufacturing practices (cGMP).
    • Record and document procedures with detail and accuracy. This includes batch records, training records, logbooks, standard operating procedures (SOPs) and validation protocols.
    • Execute quality systems (includes: critical work orders, change requests, engineering change, deviations, corrective action preventative action (CAPA)).
    • Create and revise standard operating procedures, batch records, specifications, etc.
    • Weigh and prepare culture media, buffers, and solutions.
    • Coordination and collaboration of activities with other departments, and with vendors
    • Sample solutions and perform analytical assays (including cell counts, pH, conductivity, etc.)
    • Perform technical training (including hands-on and class-based training)
    • Identify and implement equipment and process improvements.
    • Plant cleaning (including floors, benches, fermenters, equipment, etc.) waste disposal, lean manufacturing and good manufacturing practices (GMP)/compliance.

    Qualifications

    QUALIFICATIONS/REQUIREMENTS:

    • Knowledge of chromatography equipment (columns, skids, flow/UV/pH/conductivity/etc. sensors), filtration equipment, solution preparation equipment (laminar air flow hood, agitator mixers, bench top meters) are essential for this position.
    • Attention to detail and accuracy for record keeping and documentation is mandatory in this position
    • Team work and communication are key attributes needed for this position, as this role will be part of a small team within downstream purification. A collaborative attitude and a positive work ethic are key traits for success.

    Education and Experience

    • 2 years of college science in Cell Biology, Biochemistry, Chemistry, Biology, with 2 to 4 years of related experience
    • Or 4 to 8 years of experience and/or training, or equivalent combination of education and experience.

     Essential requirements

    • Skills in Biological/Chemical Sciences, Math and English.
    • Knowledge of cGMP’s
    • Able to work independently as part of a team or lead a team on assigned projects.
    • Effective organizational and solid record-keeping skills
    • Effective communication skills
    • Ability to lift >50lbs, stand on feet for 2 hours, squat, crawl, bend and work in loud, wet, and hot/cold environments
    • Ability to stand and handle repetitive motions for an extended period of time
    • Ability to use vision to differentiate colors
    • Effective hearing capabilities
    • Ability to work comfortably with large equipment

    Additional requirements 

    • Able to work a flexible schedule as needed
    • Accessibility via Cell Phone      
    • Work a nonstandard schedule
    • Work evening or night shift hours 
    • Provide coverage for other positions, shifts, or functions

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