Agenus

  • Scientist/ Sr. Scientist Cancer Immunology

    Job Locations US-MA-Lexington
    Job ID
    2018-1369
    Category
    Research
  • Overview

    We are seeking a highly motivated Scientist to join the Immunomodulatory Drug Discovery group (Cancer Immunology) at Agenus, Lexington, MA. A strong background in immunology as evidenced by peer reviewed publications is required for this position. The successful candidate will work as part of an integrated research team to identify and characterize novel therapeutic targets for cancer immunotherapy. He/she will be expected to work independently, and to design, execute and interpret experiments in the collaborative global research environment at Agenus. In addition, the candidate will lead research initiatives to evaluate cross-talk between signaling networks that contribute to immune suppression and facilitate neoplastic growth. He/she would be tasked with developing this research into novel therapeutic hypotheses, with an expectation that novel findings will be published in impactful journals.

    Responsibilities

    A PhD and post-doctoral training in immunology or oncology is required. A minimum of 3 years of research experience with demonstrated academic/industry achievement, as evidenced by publications in high impact journals, is required. Additional experience in antibody-based immunotherapies, molecular biology, in vitro study of human/primate immune cell assays and signal transduction pathways are encouraged. Candidates should have excellent communication skills, be able to distill complex ideas and articulate innovative solutions, and be dedicated to translating basic translational research insights into impactful human therapies.

    Qualifications

    • Design and execute research plans to discover and validate novel therapeutic concepts in the areas of cancer immunotherapy
    • Lead the development of novel immune assays to validate the effect of drug candidates on immune activation
    • Evaluate immune readouts (pharmacodynamic endpoints) that can be incorporated in an early clinical development setting
    • Evaluate external cutting-edge technologies for early-stage discovery and clinical biomarker initiatives
    • Represent Agenus as the scientific lead for research projects internally, and with external partners
    • Collaborate with internal teams on the implementation of biomarker assays for early clinical trials
    • Provide input on IND/NDA/BLA preparation activities.
    • Set up collaborations with academic partners and interface with study investigators, scientific and corporate partners
    • Facilitate productive research interactions across groups at Agenus
    • Demonstrate excellent communication skills (interpersonal and in group forums)
    • Mentor and lead research associates, scientists and postdoctoral fellows, as required

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