Agenus (Lexington, MA) is seeking a highly talented and motivated Scientist / Senior Scientist to join our Cellular Immunology function. In this position, you will work as part of an integrated research team focused on identifying novel cancer targets and in the development and characterization of cellular immunotherapeutic agents directed at these targets. In particular, you will have ‘hands on’ expertise with innate lymphocytes (preferably human). Additionally, you will be expected to perform experiments contributing to the larger team's effort evaluating how our immunotherapeutic cellular candidates affect immune suppression and neoplastic growth. Specifically, you will be central to identifying and testing optimal therapeutic cellular agent platforms and how to armor these to attack tumors. In this highly collaborative research environment, you will be expected to develop therapeutic hypotheses with the additional goal of publishing novel findings in high impact journals. This role would involve experimental design and execution (direct Lab. work) and recruitment, training (where needed) and supervision of technical staff as well as interpretation and presentation of results internally, to partners and externally.
Work synergistically within an interdisciplinary team of scientists and contribute in the development and implementation of the overall Agenus cancer immunology research strategies
• Evaluate external cutting-edge technologies for early-stage discovery and clinical biomarker initiatives as well as competitive evaluation
• Represent Agenus as the scientific lead for research projects internally, externally and with external partners
• Provide scientific input on patent and IND/NDA/BLA preparation activities
• Interface with clinical study investigators, scientific and corporate collaborators
• Contribute generously to the overall science base at Agenus
• A PhD. in cellular or molecular immunology and successful postdoctoral training
• Expertise in human and/or mouse innate lymphocyte immunology
• Experience with current immunological techniques including human and/or rodent immune cell function assays, multicolor flow cytometry, cell separation methods, ELISA, multiplex assays, T cell proliferation assays and/or ELISpots
• Experience in antibody or cell-based immunotherapies in vivo strongly preferred
• Additional experience with molecular biology and familiarity with basic bioinformatics preferred
• Candidates should be collaborative, have excellent communication skills, be able to distill complex ideas, articulate innovative solutions, and be dedicated to translating preclinical research insights into impactful human therapies
• Additional Senior Scientist requirements: 10+ years of post-doctoral research experience with demonstrated high academic &/or industry achievement, as evidenced by publications in impactful recognized area journals.