Senior Research Associate or Associate Scientist

Job Locations US-MA-Lexington
Job ID


The Agenus Immuno-modulatory Drug Discovery group (Lexington, MA) is seeking an experienced and highly talented and motivated senior research associate to contribute to the team's efforts of characterizing immunotherapeutic drug candidates aiming to advance research stage programs into early clinical development.

The successful candidate will have primary responsibilities to identify and characterize novel therapeutic targets and antibody-based cancer immunotherapies directed at these targets. He/she has strong analytical skills and is expected to work independently in designing, performing, and interpreting immunology-based assays. The selected candidate will provide clear and concise data summaries for technical reports, laboratory protocols, presentations and communication with collaboration partners. The position offers the successful candidate exciting opportunities to develop skills and gain expertise in immuno-oncology as part of an innovative and collaborative team committed to discover, develop, and deliver novel medicines for the treatment of cancer.


  • Perform cell-based phenotyping and functional assays designed to characterize the efficacy of drug candidates
  • Proactively propose, evaluate, and troubleshoot novel assays, methodologies, and technologies needed to establish mechanisms of action for drug candidates in different immune cell subsets
  • Design and optimize antibody panels for flow cytometric phenotyping of immune cell subsets
  • Maintain and expand sensitive primary immune cell cultures and optimize culture conditions
  • Careful plan and execute experimental work in an organized manner within agreed timelines, while maintaining clear and accurate research documentation
  • Communicate relevant progress in assay development within the team, across functions, and to collaboration partners


The candidate is expected to have a MS or PhD degree in immunology, cancer biology or a related field with a minimum of 3-7 years (MS) or 2-4 years (PhD) of experience, respectively. We are seeking candidates that have:

  • Significant experience with tissue culture procedures, including isolation, culture and differentiation of primary immune cells,
  • Strong expertise in designing multi-color antibody panels and performing flow cytometry-based phenotyping of cells, additional experience with cell sorting is preferred,
  • Strong expertise in designing and performing immunology-based assays and evidence of understanding the principles, techniques, and assays employed to characterize antibody-based cancer therapies. Experience with characterizing multi-specific antibodies is a plus,
  • Expertise in molecular biology and biochemical methodologies for cell engineering is preferred,
  • Familiarity with in vivo models of immune disease or oncology is a plus,
  • Strong written and verbal communication skills for preparing and delivering oral presentations, technical documents, and project report summaries,
  • Track record of success as evidenced by publications and/or sustained contributions in the biopharmaceutical industry.


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